Synergism between Ca 2+ and Rho‐kinase signaling during pulmonary arterial vasoconstriction in chronic hypoxic newborn lamb
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چکیده
منابع مشابه
Ca sensitization during sustained hypoxic pulmonary vasoconstriction is endothelium dependent
Robertson, Tom P., Philip I. Aaronson, and Jeremy P. T. Ward. Ca2 sensitization during sustained hypoxic pulmonary vasoconstriction is endothelium dependent. Am J Physiol Lung Cell Mol Physiol 284: L1121–L1126, 2003. First published February 28, 2003; 10.1152/ajplung.00422. 2002.—The main aim of this study was to determine the effects of endothelium removal on tension and intracellular Ca2 ([Ca...
متن کاملHypoxic Pulmonary Vasoconstriction and Chronic Lung Disease
Erik R. Swenson, MD Departments of Medicine and Physiology and Biophysics University of Washington VA Puget Sound Health Care System Seattle, WA Hypoxic vasoconstriction in the lung is a unique and fundamental characteristic of the pulmonary circulation. It functions in health and disease states to better preserve ventilation-perfusion matching by diverting blood flow to better ventilated regio...
متن کاملCa signaling in hypoxic pulmonary vasoconstriction: effects of myosin light chain and Rho kinase antagonists
Wang J, Weigand L, Foxson J, Shimoda LA, Sylvester JT. Ca signaling in hypoxic pulmonary vasoconstriction: effects of myosin light chain and Rho kinase antagonists. Am J Physiol Lung Cell Mol Physiol 293: L674–L685, 2007. First published June 15, 2007; doi:10.1152/ajplung.00141.2007.—Antagonists of myosin light chain (MLC) kinase (MLCK) and Rho kinase (ROK) are thought to inhibit hypoxic pulmon...
متن کاملHypoxic pulmonary vasoconstriction.
Humans encounter hypoxia throughout their lives. This occurs by destiny in utero, through disease, and by desire, in our quest for altitude. Hypoxic pulmonary vasoconstriction (HPV) is a widely conserved, homeostatic, vasomotor response of resistance pulmonary arteries to alveolar hypoxia. HPV mediates ventilation-perfusion matching and, by reducing shunt fraction, optimizes systemic Po(2). HPV...
متن کاملHypoxic pulmonary vasoconstriction.
Hypoxic pulmonary vasoconstriction is a local reflex in the lung that diverts blood away from poorly oxygenated regions. Improvements in understanding of modulators of this response have led to pharmacologic methods whereby V/Q matching may potentially be improved in certain types of pulmonary pathology and during anesthesia for thoracic surgical procedures.
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.1023.16